June 1-5, 2012, Chicago, IL - Researchers from the Bing Center for WM attended the 2012 Annual ASCO Meeting and Exposition, which was held at McCormick Place. There they presented 3 posters including findings from the first whole genome sequencing project for WM, and continuing investigations into the MYD88 signaling pathway, L265P Mutation, and BTK-inhibitor PCI-32765.




For more information about the American Society of Clinical Oncology (ASCO) annual meeting and exposition, please visit their website at http://chicago2012.asco.org/




ASCO 2012: Bing Center Poster Presentations


Click the hyperlink to download the full-size poster as a PDF file


Zachary Hunter: Use of whole genome sequencing to identify highly recurrent somatic mutations in Waldenström’s macroglobulinemia. Note: This file is 7MB in size, which may affect the downloading time.





Lian Xu: Detection of the MYD88 L265P Mutation in Waldenström's Macroglobulinemia Using a Highly Sensitive Allele-Specific PCR Assay.





Guang Yang: BTK participates in MYD88 signaling in malignant cells expressing the L265P mutation in Waldenstrom’s Macroglobulinemia, and shows robust tumor cell killing with the BTK-inhibitor PCI-32765 in combination with MYD88 pathway inhibitors.